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The three Halliwell sisters have always been different in many ways, not just from the world around them,but from each other. Though bound together by blood and destiny, these twentysomething women could not be further apart. The oldest sister, Prue (Shannen Doherty), determinedly driven to succeed in her life, disdains the free-spirted eccentrics of Phoebe (Alyssa Milano), the youngest on of the three. Piper (Holly Marie Combs), the earthy and creative middle sister, believes life is best navigated with sense of humor and often finds herself in a role of mediator between the other two girls. The siblings were willed the house of their childhood which they inharmoniously share, a grand and mysterious Victorian manor that has been in their family for untold generations and defines the term fixer-upper.

Yet, the discovery that these three sisters are powerful good witches, foretold as charmed ones, creates a bond that reaches far beyond petty sisterly grudges. They must band together to keep their otherworldly witchcraft a secret and vanquish all comers.